Job Description
Cranleigh STEM has partnered with an exciting CDMO organisation that supports biotech companies with the development and manufacture of complex biological drugs and innovative therapies. Based at their state-of-the-art facility in Boston they have a passionate and committed team of individuals all working towards the same goal of advancing their clients’ products from development to commercial launch.
We are looking for a Senior Bioanalytical Chemist to be part of their dedicated team…
Location: Boxborough, Boston
Salary: $. Competitive
Benefits: Bonus, Medical Plan, Sponsored Insurance, Paid Time Off Policy
As a senior bioanalytical chemist, you will work as part of a multidisciplinary team, supporting the process, analytical, development and data science divisions. You will play a pivotal role in the development and implementation of process analytical technologies ‘PAT’ for in-line monitoring and real-time control of mRNA therapeutics production.
To be considered you should possess extensive expertise in running biochemical assays and instruments including Raman spectroscopy, HPLC and UPLC, UV/Vis spectroscopy and in analyzing the resulting data. In addition, possess a solid understanding of the theories and principles of analytical chemistry and biochemistry.
Key Responsibilities:
- Identification of critical process parameters (CPP) and monitoring critical quality attributes in the mRNA process.
- Technology scouting, feasibility testing, and benchmarking against current methods.
- Collecting in-process data to support the Data Science and chemometrics team in multivariate model development.
- Run assays including Raman spectroscopy, HPLC and UPLC, UV/Vis spectroscopy, and other common biochemical assays.
- Support the Process Science engineers in running in vitro transcription (IVT), tangential flow filtration (TFF), and multicolumn chromatography equipment.
- Contribute to the team’s review of research papers, intellectual property, and current literature to propose novel techniques for process improvement and optimization in both PD and GMP environments.
Skills and experience required:
- Degree or PhD in Chemistry or Biochemistry.
- Expertise in running biochemical assays and instruments (e.g.: Raman spectroscopy, HPLC and UPLC, UV/Vis spectroscopy) and in analyzing the resulting data.
- Solid understanding of the theories and principles of analytical chemistry and biochemistry.
- Experience with processing equipment (e.g.: IVT reactions, TFF, multicolumn chromatography).
- Desire to learn and advance existing skills, with a proven track record of critical thinking and problem-solving.
- Self-motivated, ability to work independently, strong work ethic, attention to detail, can be flexible with changing priorities.
If you are a driven individual looking for an exciting opportunity to be part of a growing CDMO within the biotech and pharma sector, please apply or reach out to me directly at katie@cranleighstem.co.uk/ +1 (332) 206-1441